Cisplatin renal function

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August undefined, 2024

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in the glomerular filtration rate, the elimination of cisplatin is delayed in patients with cancer, and, as a result, tubular and glomerular injuries subsequently develop. http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf

Cisplatin Drugs BNF NICE

WebNational Center for Biotechnology Information WebJan 11, 2024 · During and after cisplatin treatment. Renal function should be closely monitored before each dose of chemotherapy every 1–2 weeks. foam mat for kitchen

Risk factors for renal toxicity after inpatient cisplatin ...

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … WebCisplatin can enter the renal tubular cells by either passive diffusion or active transport. Previous studies have indicated that movement of cisplatin through the renal tubular … WebMar 12, 2024 · Nephrotoxicity is a known side effect of several treatments, including cisplatin, carboplatin, ifosfamide, radiotherapy and nephrectomy, and can cause glomerular filtration rate (GFR) impairment, proteinuria, tubulopathy, and hypertension. Evidence about the long-term effects of these treatments on renal function remains inconclusive. greenwood chevy fort meade fl

Full-dose cisplatin chemotherapy combined with hemodialysis

PRODUCT INFORMATION –CISPLATIN INJECTION(CISPLATIN)

WebAfter my husbands first dose of cisplatin he was put in the hospital with poor kindey function. He was put on a renal diet.. He never received Cisplatin after that, and his kidneys are back to normal. I am curious, I believe your husband has been out of treatment for awhile. So, is this late side effects? buzz99 Member Posts: 404 May 2011 #8 WebJan 17, 2014 · Background Nephrotoxicity is the dose-limiting side effect of cisplatin justifying the assessment of renal function for dose adjustment. Objective To determine whether appropriate dose adjustment is made in patients with renal impairment using the Cockcroft–Gault (CG) or the abbreviated Modification of Diet in Renal Disease (aMDRD) … foam mat for campingWebSep 1, 2024 · Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses … foam mat foam mattress

"WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … " - Cisplatin renal function

Cisplatin renal function

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebImpaired Renal Function Cisplatin displays high tissue uptake in the kidneys and exhibits dose-related and cumulative nephrotoxicity. It is excreted mainly in the urine. The …

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WebFor cisplatin, hydration is always indicated and mannitol may be useful in selected settings. Furosemide is probably not generally useful. For carboplatin, hydration is important for patients with impaired renal function and for patients receiving high doses of drug (> or = 800 mg/m2). For ormplatin, renal toxicity appears not be prominent when ... WebMain outcome measure: Cisplatin dose in mg/m(2) based on kidney function and according to the dosing recommendations. Results: Among 1,364 cycles of cisplatin, …

WebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat Rev. 1995; 21: 33–64GFR (mL/min) Dose60 100%50–60 75%40–50 50%40 AvoidBennett 50 100%10–50 75% WebCisplatin is the first choice treatment in mediastinal germ cell tumors. However, concerns regarding increased toxicity of cisplatin hamper its administration in patients with …

WebRenal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high urinary … WebCisplatin is the first choice treatment in mediastinal germ cell tumors. However, concerns regarding increased toxicity of cisplatin hamper its administration in patients with impaired renal function.

WebJun 18, 2024 · The current use of cisplatin in regimens involving pre and posthydration with careful monitoring of diuresis in the treatment of testicular tumors is associated with …

WebFeb 16, 2016 · In our study using GFR as a measure for renal function, acute nephrotoxicity grade 2 was found in 11% of patients after the first course and in 16% after the second course of cisplatin. By comparison, when expressing nephrotoxicity in the same study population using serum creatinine levels, we observed a lower incidence of … foam mat floor tiles costcoWebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … foam mat for swimming poolWebFor cisplatin Monitoring of patient parameters Monitor full blood count. Monitor audiology. Monitor plasma electrolytes. Nephrotoxicity Monitoring of renal function is essential. … greenwood chevy used carsWebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … foam mat for inflatable poolWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … greenwood chevy hubbard car showWebClearance of cisplatin, etoposide, and ifosfamide depends on kidney function and dosages should be adjusted in patients with renal impairment. However, there is still limited data on the adherence of physicians to dosing recommendations for these drugs in cancer patients with renal impairment. Three … greenwood chevy austintown serviceWebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. greenwood chevy austintown used cars